medium size brown dog with red collar sitting on a table being listened to by a woman wearing a stethoscope and white button up shirt.

Completed Studies

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YearTitle of ProjectObjectiveStudy Information and/or Publication(s)
2024Investigating Biomarkers of Metronomic Chemotherapy Treatment in Dogs with Soft Tissue SarcomaMetronomic chemotherapy (LDM) is a new form of treatment, defined as the low-dose daily administration of chemotherapy drugs. We do not know exactly how these drugs work (changes that occur inside the tumour) or the most optimal dose and schedule for STS treatment.Click Here to View the LDM Study Infographic
2024Investigating Carboplatin Chemotherapy as a Post-Surgical treatment for Splenic Hemangiosarcoma in DogsEven with standard of care treatments, Doxorubicin
chemotherapy and tumour resection, HSA has a very guarded prognosis. Carboplatin is another common chemotherapy agent and has been shown to have a similar effect and an improved tolerability in dogs diagnosed with Osteosarcoma, when compared to Doxorubicin.
Click Here to View the HSA Study Infographic
2023Evaluating the Use of IV Fluids on Blood Values in Critically Ill DogsIntravenous (IV) fluid therapy is often used for hospitalized patients. We don’t really know how the use of IV fluids impacts blood vessels, but Hyaluronic acid (HA) may be a biomarker (or indicator) of these changes. Using HA measurements, we can better understand the effect of fluid therapies in critically ill dogs and the HA concentrations related to various diagnoses.Click Here to View the Infographic for the HA Study in Dogs
2023
Evaluating the Use of Magnesium to Control Pain and Inflammation Following Spinal Surgery in DogsNot only is magnesium an important ion in the body but it also has anti-inflammatory properties, is inexpensive, very easy to administer, it is not a controlled drug or addictive, and side effects are extremely rare. By evaluating the use of magnesium in combination with standard of care opioids, we can evaluate its analgesic and anti-inflammatory effect.Click to View the Infographic for the Magnesium Study
2023Measuring How Drugs Affect the Speed of Transit Through the Gastrointestinal Tract via a Swallowed Video Recording DeviceCapsule endoscopy (CE) has revolutionized the approach of endoscopy in humans and dogs, allowing for the evaluation of the entire gut in a minimally invasive way, without the need for general anesthesia. In order to use this innovative technology for clinical practice in dogs, it is crucial that we develop an optimal protocol (using prokinetic drugs) to achieve a complete study.Click to View Infographic for AliCam Study
2023Evaluating the Use of Injected Stem Cells for Treating Synovitis in Horses (Compared to Standard of Care Treatment)Equine synovitis is a painful and debilitating condition that can require long recovery times and can often recur due to incomplete healing. Stem cell therapy may help to decrease inflammation and regenerate damaged tissues associated with synovitis.Click to View Infographic for Synovitis Horse Study
2023Comparison of Two Laboratory Systems for Hemoglobin Measurements in CatsSick cats often have anemia (a deficiency of healthy red blood cells), which when given intravenous (IV) fluids can worsen this condition. A new handheld device, the HemoCue Hb 201, requires much smaller (up to 100x) blood samples and provides quick results. Before using this device in clinical practice, we need to ensure it is as accurate as our current method, the Advia 2120.Click to View Study Infographic for HemaCue.
2023Measuring How Drugs Affect the Speed of Transit Through the Gastrointestinal Tract via a Swallowed Video Recording DeviceCapsule endoscopy (CE) has revolutionized the approach of endoscopy in humans and dogs, allowing for the evaluation of the entire gut in a minimally invasive way, without the need for general anesthesia. In order to use this innovative technology for clinical practice in dogs, it is crucial that we develop an optimal protocol (using prokinetic drugs) to achieve a complete study.Click to View the Study Infographic.
2023Characterization of Innate Lymphoid Cells in Canine Blood The goal of this study is to determine how commercial compounds could be used to identify all subsets of innate lymphoid cells in the circulation of healthy dogs and expand them in our laboratory for further characterizations.
2022Comparison of Instrument Size when Conducting Routine Laparoscopic Liver Biopsy Procedures in Small DogsTo determine if using smaller laparoscopy instruments for liver biopsies in small dogs can provide the same diagnostic samples to those obtained using standard instruments.
2022Fecal Transplants for Dogs with IBDhttps://pubmed.ncbi.nlm.nih.gov/36256653/
2022Does Age Influence Changes to the Heart Structure and Function in Cats?Click to View the Study Infographic
2022Establishment of Reference Intervals for Kidney Injury Molecule 1 (KIM-1) in a Healthy Feline Population
2022Understanding the Bacteria Within the Bladder in Female Cats and Dogs
2021Evaluating instrumentation and sample handling for assesssing platelet function in healthy cats
Complete Title: Evaluation Of Platelet Function In Cats: Validation Of Procyte DX For PlateletWorks And Sample Shipping For Platelet Function Analyzer – 200
2018 – to dateUnraveling the pathophysiology of feline hypertrophic cardiomyopathy (Sub-study B)Related study: https://pubmed.ncbi.nlm.nih.gov/30895910/
2018-2019Comparison of diet type and supplement use between dogs with cancer and healthy dogshttps://pubmed.ncbi.nlm.nih.gov/32304175/
2017-2018Minimal Residual Disease Detection in Canine Lymphomahttps://pubmed.ncbi.nlm.nih.gov/30885305/
2017 – to dateProfiling and validation of extracellular vesicles as circulating biomarkers in canine osteosarcoma: a DOGBONe project[Trial is currently on hold and is not recruiting new participants] https://doi.org/10.1186/s12917-018-1651-5
2016 – 2020Evaluation of sentinel LN mapping in dogs with ORAL TUMOURS using CT lymphography and intraoperative METHYLENE BLUEhttps://onlinelibrary.wiley.com/doi/10.1111/vco.12675
2016 – 2018Non-invasive detection and Quantification of Circulating Tumour Cells in Dogs with Appendicular Osteosarcomahttps://doi.org/10.1002/cyto.a.23847 
2016 – 2018Evaluating crossmatch incompatibility to increase safety of blood transfusion in cats and dogshttps://pubmed.ncbi.nlm.nih.gov/33336866/
2016 – 2018Evaluation of anesthetic blocks during forelimb surgery for analgesia in dogshttps://pubmed.ncbi.nlm.nih.gov/29366667/
2016 – 2018Diagnosing immune mediated hemolytic anemia (IMHA) in Catshttps://pubmed.ncbi.nlm.nih.gov/29341177/
2016 – 2018Improving characterisation of respiratory disease in cats1: https://pubmed.ncbi.nlm.nih.gov/30657606/
2: https://pubmed.ncbi.nlm.nih.gov/23531058/
3: https://pubmed.ncbi.nlm.nih.gov/24370250/
4: https://pubmed.ncbi.nlm.nih.gov/30372158/
2016 – 2017Cranial cruciate ligament rupturehttps://pubmed.ncbi.nlm.nih.gov/32357267/
2016 – 2017Investigation of high flow nasal cannula respiratory support systems in brachycephalic dogs recovering from general anesthesia1. https://pubmed.ncbi.nlm.nih.gov/30861261/
2. https://onlinelibrary.wiley.com/doi/abs/10.1111/vec.12971?campaign=wolearlyview
2016-2017Investigation of high flow nasal cannula respiratory support systems in dogs with clinical disease1. https://pubmed.ncbi.nlm.nih.gov/30861261/
2. https://onlinelibrary.wiley.com/doi/full/10.1111/vec.12970
2015-2018 (TBC)Oncolytic viral vaccine therapy of feline mammary carcinoma1: https://pubmed.ncbi.nlm.nih.gov/29146945/
2: http://dx.doi.org/10.1111/jvim.13952
2015 – 2018microRNA Profiling for Diagnosis and Prognosis in Canine Multicentric Lymphomahttps://doi.org/10.1371/journal.pone.0226357; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905567/
2015 – 2018Dobermans with preclinical dilated cardiomyopathy (DCM)https://pubmed.ncbi.nlm.nih.gov/30825889/
2015 – 2017Food Allergies in Dogshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380261/
2015 – 2017Blood clotting ability in dogs with immune mediated hemolytic anemia (IMHA)1: https://pubmed.ncbi.nlm.nih.gov/28821259/
2: https://pubmed.ncbi.nlm.nih.gov/32293441/
2014-2018The impact of obesity treatment on the feline fecal microbiome1: https://pubmed.ncbi.nlm.nih.gov/28821259/
2: https://pubmed.ncbi.nlm.nih.gov/32293441/
2014-2015?The effects of pre-storage leukoreduction on inflammation induced by blood transfusion in critically ill dogshttps://pubmed.ncbi.nlm.nih.gov/31218809/
2014-2015 (TBC)Measurement of pre-treatment levels and early changes in serum cytokines of dogs with multicentric lymphoma treated with a CHOP protocolhttps://pubmed.ncbi.nlm.nih.gov/27863540/
2014-2015 (TBC)Evaluation of the antihistaminic effects of diphenyhydramine in dogs undergoing excision of mast cell tumors1: https://pubmed.ncbi.nlm.nih.gov/28967819/
2: https://pubmed.ncbi.nlm.nih.gov/26813802/
2014-2015 (TBC)Evaluating the association between aspirin and clopidogrel metabolite levels in blood and platelet function in healthy cats receiving commonly prescribed anti-platelet medications1: https://pubmed.ncbi.nlm.nih.gov/25943127/
2: https://pubmed.ncbi.nlm.nih.gov/27170631/
2014-2015Canine Stem Cellshttps://pubmed.ncbi.nlm.nih.gov/21418324/
2014 – to-datePrognostication of canine T-Cell lymphomahttps://pubmed.ncbi.nlm.nih.gov/28895866
2014 – to-dateFeline acute kidney injury study1: https://pubmed.ncbi.nlm.nih.gov/30461328/
2: https://pubmed.ncbi.nlm.nih.gov/28129098/
3: https://pubmed.ncbi.nlm.nih.gov/25274439/
2013-2014 (TBC)Biological variability of platelet function testing in healthy dogs1: https://pubmed.ncbi.nlm.nih.gov/23648208/
2: https://pubmed.ncbi.nlm.nih.gov/29194772/
3: https://pubmed.ncbi.nlm.nih.gov/26397961/
4: https://pubmed.ncbi.nlm.nih.gov/29578657/
2013-2014Using ribosomal RNA disruption as a predictor of early relapse in canine lymphomahttps://pubmed.ncbi.nlm.nih.gov/31842875/
2013-2014Vitamin D status in canine cancer patients and the relationship with dietary vitamin D intakehttps://pubmed.ncbi.nlm.nih.gov/28941306/
2013-2014Safety corridors and biomechanical testing of ventral atlantoaxial stabilisation techniques in dogs1: https://pubmed.ncbi.nlm.nih.gov/29202504/
2: https://pubmed.ncbi.nlm.nih.gov/30125913/
3: https://pubmed.ncbi.nlm.nih.gov/27599482/
2013-2014Image guided percutaneous injection of gelified ethanol for treatment of intervertebral disc disease in dogs – Part IIhttps://pubmed.ncbi.nlm.nih.gov/26626409/
2013-2014Anesthetic and cardio-respiratory effects of propofol or alfaxalone with or without diazepam during MRI in dogshttps://pubmed.ncbi.nlm.nih.gov/28967477/
2013-2014Development of a novel ultrasound-guided transurethral biopsy device for dogs and catshttps://pubmed.ncbi.nlm.nih.gov/31194657/
2009 – to-dateCompanion Animal Tumour Sample Bankhttps://icci.uoguelph.ca/companion-animal-tumour-sample-bank/
~2014Silver coated urinary catheter1: https://pubmed.ncbi.nlm.nih.gov/30398417/ precursor pre-clinical studies:
2: https://pubmed.ncbi.nlm.nih.gov/25909371/
3: https://pubmed.ncbi.nlm.nih.gov/25969583/
Not availableEvaluation of abdominal fluid in dogs – GI Sxhttps://pubmed.ncbi.nlm.nih.gov/26130056/
2016Randomized, blinded study comparing fentanyl and hydromorphone infusions to control pain in canine ICU patientshttps://pubmed.ncbi.nlm.nih.gov/30082181/
Not availableNeutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemiahttps://pubmed.ncbi.nlm.nih.gov/27112380/
Not availableEffects of omega-3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet functionhttps://pubmed.ncbi.nlm.nih.gov/29120035/
Not availableExpression of microRNAs miR-21 and miR-181c in cerebrospinal fluid and serum in canine meningoencephalomyelitis of unknown originhttps://pubmed.ncbi.nlm.nih.gov/27687938/