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| Year | Title of Project | Objective | Study Information and/or Publication(s) |
|---|---|---|---|
| 2024 | Treatment of Elbow Dysplasia in Dogs with Canine Stem Cells | Joint inflammation and associated diseases are common in dogs, with around 20% of dogs developing osteoarthritis (OA). Large to giant breed dogs are often diagnosed with elbow dysplasia (ED), which can lead to OA later in life. Current treatments, such as medications (non-steroidal anti-inflammatories (NSAIDs)) and surgery, might not work for all dogs. Mesenchymal stromal cells (MSCs) have shown anti-inflammatory effects and could be a treatment option for immune and inflammatory disorders in dogs, like ED. This alternative may have better safety and efficacy and require less owner compliance compared to NSAIDs. | Click to View the ED Study Infographic |
| 2024 | Evaluating Potential Blood Biomarkers for Feline Heart Disease (HCM) | Researchers at OVC have identified a set of genes that are differently expressed in hearts from cats with Hypertrophic Cardiomyopathy (HCM) compared to healthy cats. The products of these genes are known to be released into the blood and might therefore be useful as markers for HCM. | Click to View the HCM Biomarker Study Infographic |
| 2024 | Comparison of Two Surgical Techniques For The Treatment of Brachycephalic Airway Disease in French Bulldogs | Currently in veterinary patients, standard of care surgery for BOAS is a soft palate resection (staphylectomy). Given that some dogs still suffer from breathing difficulties following surgery, modifications that aim to provide a greater opening of the airway have been proposed. One of these procedures is the folded flap palatoplasty however a comparison of these techniques as it relates to clinical outcome has not been performed. | Click to View BOAS Study Infographic |
| 2024 | Investigating Biomarkers of Metronomic Chemotherapy Treatment in Dogs with Soft Tissue Sarcoma | Metronomic chemotherapy (LDM) is a new form of treatment, defined as the low-dose daily administration of chemotherapy drugs. We do not know exactly how these drugs work (changes that occur inside the tumour) or the most optimal dose and schedule for STS treatment. | Click Here to View the LDM Study Infographic |
| 2024 | Investigating Carboplatin Chemotherapy as a Post-Surgical treatment for Splenic Hemangiosarcoma in Dogs | Even with standard of care treatments, Doxorubicin chemotherapy and tumour resection, HSA has a very guarded prognosis. Carboplatin is another common chemotherapy agent and has been shown to have a similar effect and an improved tolerability in dogs diagnosed with Osteosarcoma, when compared to Doxorubicin. | Click Here to View the HSA Study Infographic |
| 2023 | Evaluating the Use of IV Fluids on Blood Values in Critically Ill Dogs | Intravenous (IV) fluid therapy is often used for hospitalized patients. We don’t really know how the use of IV fluids impacts blood vessels, but Hyaluronic acid (HA) may be a biomarker (or indicator) of these changes. Using HA measurements, we can better understand the effect of fluid therapies in critically ill dogs and the HA concentrations related to various diagnoses. | Click Here to View the Infographic for the HA Study in Dogs |
| 2023 | Evaluating the Use of Magnesium to Control Pain and Inflammation Following Spinal Surgery in Dogs | Not only is magnesium an important ion in the body but it also has anti-inflammatory properties, is inexpensive, very easy to administer, it is not a controlled drug or addictive, and side effects are extremely rare. By evaluating the use of magnesium in combination with standard of care opioids, we can evaluate its analgesic and anti-inflammatory effect. | Click to View the Infographic for the Magnesium Study |
| 2023 | Measuring How Drugs Affect the Speed of Transit Through the Gastrointestinal Tract via a Swallowed Video Recording Device | Capsule endoscopy (CE) has revolutionized the approach of endoscopy in humans and dogs, allowing for the evaluation of the entire gut in a minimally invasive way, without the need for general anesthesia. In order to use this innovative technology for clinical practice in dogs, it is crucial that we develop an optimal protocol (using prokinetic drugs) to achieve a complete study. | Click to View Infographic for AliCam Study |
| 2023 | Evaluating the Use of Injected Stem Cells for Treating Synovitis in Horses (Compared to Standard of Care Treatment) | Equine synovitis is a painful and debilitating condition that can require long recovery times and can often recur due to incomplete healing. Stem cell therapy may help to decrease inflammation and regenerate damaged tissues associated with synovitis. | Click to View Infographic for Synovitis Horse Study |
| 2023 | Comparison of Two Laboratory Systems for Hemoglobin Measurements in Cats | Sick cats often have anemia (a deficiency of healthy red blood cells), which when given intravenous (IV) fluids can worsen this condition. A new handheld device, the HemoCue Hb 201, requires much smaller (up to 100x) blood samples and provides quick results. Before using this device in clinical practice, we need to ensure it is as accurate as our current method, the Advia 2120. | Click to View Study Infographic for HemaCue. |
| 2023 | Measuring How Drugs Affect the Speed of Transit Through the Gastrointestinal Tract via a Swallowed Video Recording Device | Capsule endoscopy (CE) has revolutionized the approach of endoscopy in humans and dogs, allowing for the evaluation of the entire gut in a minimally invasive way, without the need for general anesthesia. In order to use this innovative technology for clinical practice in dogs, it is crucial that we develop an optimal protocol (using prokinetic drugs) to achieve a complete study. | Click to View the Study Infographic. |
| 2023 | Characterization of Innate Lymphoid Cells in Canine Blood | The goal of this study is to determine how commercial compounds could be used to identify all subsets of innate lymphoid cells in the circulation of healthy dogs and expand them in our laboratory for further characterizations. | |
| 2022 | Comparison of Instrument Size when Conducting Routine Laparoscopic Liver Biopsy Procedures in Small Dogs | To determine if using smaller laparoscopy instruments for liver biopsies in small dogs can provide the same diagnostic samples to those obtained using standard instruments. | |
| 2022 | Fecal Transplants for Dogs with IBD | https://pubmed.ncbi.nlm.nih.gov/36256653/ | |
| 2022 | Does Age Influence Changes to the Heart Structure and Function in Cats? | Click to View the Study Infographic | |
| 2022 | Establishment of Reference Intervals for Kidney Injury Molecule 1 (KIM-1) in a Healthy Feline Population | ||
| 2022 | Understanding the Bacteria Within the Bladder in Female Cats and Dogs | ||
| 2021 | Evaluating instrumentation and sample handling for assesssing platelet function in healthy cats Complete Title: Evaluation Of Platelet Function In Cats: Validation Of Procyte DX For PlateletWorks And Sample Shipping For Platelet Function Analyzer – 200 | ||
| 2018 – to date | Unraveling the pathophysiology of feline hypertrophic cardiomyopathy (Sub-study B) | Related study: https://pubmed.ncbi.nlm.nih.gov/30895910/ | |
| 2018-2019 | Comparison of diet type and supplement use between dogs with cancer and healthy dogs | https://pubmed.ncbi.nlm.nih.gov/32304175/ | |
| 2017-2018 | Minimal Residual Disease Detection in Canine Lymphoma | https://pubmed.ncbi.nlm.nih.gov/30885305/ | |
| 2017 – to date | Profiling and validation of extracellular vesicles as circulating biomarkers in canine osteosarcoma: a DOGBONe project | [Trial is currently on hold and is not recruiting new participants] https://doi.org/10.1186/s12917-018-1651-5 | |
| 2016 – 2020 | Evaluation of sentinel LN mapping in dogs with ORAL TUMOURS using CT lymphography and intraoperative METHYLENE BLUE | https://onlinelibrary.wiley.com/doi/10.1111/vco.12675 | |
| 2016 – 2018 | Non-invasive detection and Quantification of Circulating Tumour Cells in Dogs with Appendicular Osteosarcoma | https://doi.org/10.1002/cyto.a.23847 | |
| 2016 – 2018 | Evaluating crossmatch incompatibility to increase safety of blood transfusion in cats and dogs | https://pubmed.ncbi.nlm.nih.gov/33336866/ | |
| 2016 – 2018 | Evaluation of anesthetic blocks during forelimb surgery for analgesia in dogs | https://pubmed.ncbi.nlm.nih.gov/29366667/ | |
| 2016 – 2018 | Diagnosing immune mediated hemolytic anemia (IMHA) in Cats | https://pubmed.ncbi.nlm.nih.gov/29341177/ | |
| 2016 – 2018 | Improving characterisation of respiratory disease in cats | 1: https://pubmed.ncbi.nlm.nih.gov/30657606/ 2: https://pubmed.ncbi.nlm.nih.gov/23531058/ 3: https://pubmed.ncbi.nlm.nih.gov/24370250/ 4: https://pubmed.ncbi.nlm.nih.gov/30372158/ | |
| 2016 – 2017 | Cranial cruciate ligament rupture | https://pubmed.ncbi.nlm.nih.gov/32357267/ | |
| 2016 – 2017 | Investigation of high flow nasal cannula respiratory support systems in brachycephalic dogs recovering from general anesthesia | 1. https://pubmed.ncbi.nlm.nih.gov/30861261/ 2. https://onlinelibrary.wiley.com/doi/abs/10.1111/vec.12971?campaign=wolearlyview | |
| 2016-2017 | Investigation of high flow nasal cannula respiratory support systems in dogs with clinical disease | 1. https://pubmed.ncbi.nlm.nih.gov/30861261/ 2. https://onlinelibrary.wiley.com/doi/full/10.1111/vec.12970 | |
| 2015-2018 (TBC) | Oncolytic viral vaccine therapy of feline mammary carcinoma | 1: https://pubmed.ncbi.nlm.nih.gov/29146945/ 2: http://dx.doi.org/10.1111/jvim.13952 | |
| 2015 – 2018 | microRNA Profiling for Diagnosis and Prognosis in Canine Multicentric Lymphoma | https://doi.org/10.1371/journal.pone.0226357; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905567/ | |
| 2015 – 2018 | Dobermans with preclinical dilated cardiomyopathy (DCM) | https://pubmed.ncbi.nlm.nih.gov/30825889/ | |
| 2015 – 2017 | Food Allergies in Dogs | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380261/ | |
| 2015 – 2017 | Blood clotting ability in dogs with immune mediated hemolytic anemia (IMHA) | 1: https://pubmed.ncbi.nlm.nih.gov/28821259/ 2: https://pubmed.ncbi.nlm.nih.gov/32293441/ | |
| 2014-2018 | The impact of obesity treatment on the feline fecal microbiome | 1: https://pubmed.ncbi.nlm.nih.gov/28821259/ 2: https://pubmed.ncbi.nlm.nih.gov/32293441/ | |
| 2014-2015? | The effects of pre-storage leukoreduction on inflammation induced by blood transfusion in critically ill dogs | https://pubmed.ncbi.nlm.nih.gov/31218809/ | |
| 2014-2015 (TBC) | Measurement of pre-treatment levels and early changes in serum cytokines of dogs with multicentric lymphoma treated with a CHOP protocol | https://pubmed.ncbi.nlm.nih.gov/27863540/ | |
| 2014-2015 (TBC) | Evaluation of the antihistaminic effects of diphenyhydramine in dogs undergoing excision of mast cell tumors | 1: https://pubmed.ncbi.nlm.nih.gov/28967819/ 2: https://pubmed.ncbi.nlm.nih.gov/26813802/ | |
| 2014-2015 (TBC) | Evaluating the association between aspirin and clopidogrel metabolite levels in blood and platelet function in healthy cats receiving commonly prescribed anti-platelet medications | 1: https://pubmed.ncbi.nlm.nih.gov/25943127/ 2: https://pubmed.ncbi.nlm.nih.gov/27170631/ | |
| 2014-2015 | Canine Stem Cells | https://pubmed.ncbi.nlm.nih.gov/21418324/ | |
| 2014 – to-date | Prognostication of canine T-Cell lymphoma | https://pubmed.ncbi.nlm.nih.gov/28895866 | |
| 2014 – to-date | Feline acute kidney injury study | 1: https://pubmed.ncbi.nlm.nih.gov/30461328/ 2: https://pubmed.ncbi.nlm.nih.gov/28129098/ 3: https://pubmed.ncbi.nlm.nih.gov/25274439/ | |
| 2013-2014 (TBC) | Biological variability of platelet function testing in healthy dogs | 1: https://pubmed.ncbi.nlm.nih.gov/23648208/ 2: https://pubmed.ncbi.nlm.nih.gov/29194772/ 3: https://pubmed.ncbi.nlm.nih.gov/26397961/ 4: https://pubmed.ncbi.nlm.nih.gov/29578657/ | |
| 2013-2014 | Using ribosomal RNA disruption as a predictor of early relapse in canine lymphoma | https://pubmed.ncbi.nlm.nih.gov/31842875/ | |
| 2013-2014 | Vitamin D status in canine cancer patients and the relationship with dietary vitamin D intake | https://pubmed.ncbi.nlm.nih.gov/28941306/ | |
| 2013-2014 | Safety corridors and biomechanical testing of ventral atlantoaxial stabilisation techniques in dogs | 1: https://pubmed.ncbi.nlm.nih.gov/29202504/ 2: https://pubmed.ncbi.nlm.nih.gov/30125913/ 3: https://pubmed.ncbi.nlm.nih.gov/27599482/ | |
| 2013-2014 | Image guided percutaneous injection of gelified ethanol for treatment of intervertebral disc disease in dogs – Part II | https://pubmed.ncbi.nlm.nih.gov/26626409/ | |
| 2013-2014 | Anesthetic and cardio-respiratory effects of propofol or alfaxalone with or without diazepam during MRI in dogs | https://pubmed.ncbi.nlm.nih.gov/28967477/ | |
| 2013-2014 | Development of a novel ultrasound-guided transurethral biopsy device for dogs and cats | https://pubmed.ncbi.nlm.nih.gov/31194657/ | |
| 2009 – to-date | Companion Animal Tumour Sample Bank | https://icci.uoguelph.ca/companion-animal-tumour-sample-bank/ | |
| ~2014 | Silver coated urinary catheter | 1: https://pubmed.ncbi.nlm.nih.gov/30398417/ precursor pre-clinical studies: 2: https://pubmed.ncbi.nlm.nih.gov/25909371/ 3: https://pubmed.ncbi.nlm.nih.gov/25969583/ | |
| Not available | Evaluation of abdominal fluid in dogs – GI Sx | https://pubmed.ncbi.nlm.nih.gov/26130056/ | |
| 2016 | Randomized, blinded study comparing fentanyl and hydromorphone infusions to control pain in canine ICU patients | https://pubmed.ncbi.nlm.nih.gov/30082181/ | |
| Not available | Neutrophil gelatinase-associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia | https://pubmed.ncbi.nlm.nih.gov/27112380/ | |
| Not available | Effects of omega-3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet function | https://pubmed.ncbi.nlm.nih.gov/29120035/ | |
| Not available | Expression of microRNAs miR-21 and miR-181c in cerebrospinal fluid and serum in canine meningoencephalomyelitis of unknown origin | https://pubmed.ncbi.nlm.nih.gov/27687938/ |