All Active Canine Clinical Trials

Internal Medicine


NEW STUDY – Evaluating the Impact of Elective Surgery on the Gut Bacteria of Dogs

Complete Title: Impact of Elective Orthopedic Surgery on the Fecal Microbiome of Dogs

The purpose of this research is to determine the effects of elective orthopedic surgery on the gut microbiome. The gut microbiome is a collection of bacteria and other microorganisms living within the gastrointestinal tract, including many beneficial bacteria. Surgery could impact the microbiome population, and changes in the microbiome could be linked to health status.

Inclusion criteria:

  • Dogs undergoing any elective orthopedic surgery (e.g., TPLO), with no other diagnosed illnesses in 1 month prior to surgery

Measuring How Drugs Affect the Speed of Transit Through the Gastrointestinal Tract via a Swallowed Video Recording Device

Complete Title: Effect of Metoclopramide and Erythromycin on Gastrointestinal Transit Time in Healthy Dogs Measured by Video Endoscopy

The objective of this study is to determine if the use of prokinetic drugs prior to capsule administration results in a higher rate of complete studies.

Inclusion criteria:

  • (Dogs owned by internal (OVC) or external veterinary professionals)
  • Healthy dogs ≥10 kg not on any medication affecting gut motility (i.e. prokinetics, levothyroxine or opioids) with no adverse GI signs within the last 2 months (vomiting, diarrhea, or regurgitation) and no chronic gastroenteropathy

Diagnostic Imaging


NEW STUDY – Evaluating the Effect of Minimally Invasive Surgery on the Intracranial Pressure in Dogs

Complete Title: The Effect of Laparoscopy on Intracranial Pressure as Measured by Optic Nerve Sheath Diameter

The objective of this study is to determine whether minimally invasive surgery using laparoscopy causes increases in intracranial pressure (pressure inside the skull).

Inclusion criteria:

  • Any dogs undergoing laparoscopic gastropexy and/or spay at OVC

Neurology


Are These Seizures in Dogs?

Complete Title: Are These Seizures in Canines?

The objective of this study is to analyze electroencephalogram (EEG) recording in dogs during seizure-like episodes to better diagnose and manage seizures in our pets.

Inclusion criteria:

  • Dogs that are between 6 months and 6 years of age that experience episodes similar to seizures

Do Anti-Seizure Drugs Work in Dogs?

Complete Title: Do Anti-Seizure Drugs Work in Canines?

The objective of this study is to determine how well anti-seizure drugs (ASD) work for dogs with epilepsy by recording EEG before and after a new therapy is prescribed

Inclusion criteria:

  • Dogs between 6 months and 6 years of age with normal neurologic exam and at least one year since index seizure (known as Tier I idiopathic epilepsy)
  • Any dog with Tier II idiopathic epilepsy regardless of age, neurologic exam status, or time since first onset of seizures (must have normal MRI and CSF & bloodwork)
  • Dog’s veterinarian is planning to add a new ASD regardless of previous ASD status

Oncology


NEW STUDYCan We Use a Mobile App to Measure Oral Tumours in Dogs?

Complete Title: Utility and Feasibility of Mobile Device Photogrammetry to Accurately Determine Tumour Dimensions in Dogs with Oral Tumours, a Pilot Study

An important aspect of tumour staging and prognosis is often related to tumour size. Traditionally, clinicians have relied on hand-held caliper measurements alone prior to CT to accurately obtain a baseline for their patient’s tumour and to later assess response to therapy. Incorporation of technology in the assessment of pets with cancer is important for treatment evaluation and improving follow-up including the ability to monitor disease at home, without the need to travel for recheck appointments. 

Inclusion criteria:

  • Dogs with oral tumours >1cm undergoing CT scans for standard of care treatment at either the Ontario Veterinary College or the Toronto Veterinary Emergency and Referral Hospital   

NEW STUDY – Exploring a Novel Diagnostic and Treatment Technique in Combination With Surgery for Thyroid Tumours in Dogs

Complete Title: Exploration of Nanoparticle-Enabled Image Guided Photoablation in Veterinary Patients

PORPHYSOME-enabled therapies can have an immediate impact on cancer management providing better patient outcomes. This study will evaluate the potential applications of the novel nanomedicine (PORPHYSOMES) and PDT in veterinary clinical patients with thyroid tumours.

This project is part of the Veterinary Medical Innovation Platform aligned with Dr Michelle Oblak’s research chair with OVC and Animal Health Partners!

Inclusion criteria:

  • Dogs with a confirmed freely moveable thyroid tumour interested in pursuing surgery are eligible

NEW STUDYEvaluating the Use of Fluorescence Dyes in Surgery to Identify Canine Pancreatic Cancer and Metastasis

Complete Title: Pilot Evaluation of Near Infrared Fluorescence Imaging for Intraoperative Identification of Canine Insulinoma and Their Metastasis

Near-infrared fluorescence imaging (NIRF) using Indocyanine Green (ICG), a fluorescent dye, has been previously used in a number of veterinary applications (many in clinical trials here at OVC). The use of NIRF for pancreatic mass resection in dogs has not yet been described but holds excellent potential for improving patient outcomes. The objective of this pilot study is to investigate the feasibility and utility of NIRF imaging for intraoperative characterization of pancreatic tumours and their metastases in dogs.

Inclusion criteria:

  • Dogs that are diagnosed with a pancreatic mass and scheduled for exploratory laparotomy

NEW STUDY Characterization of Innate Lymphoid Cells in Canine Blood

The goal of this study is to determine how commercial compounds could be used to identify all subsets of innate lymphoid cells in the circulation of healthy dogs and expand them in our laboratory for further characterizations.

Inclusion criteria:

  • INTERNAL STUDY – OVC Faculty, Staff and Student Owned Pets Only
  • Healthy adult dogs will be enrolled in the study. Exclusion criteria include body weight below 5 kg and above 45 kg, systemic disease, systemic immunomodulatory medication or supplement within the last two weeks (including corticosteroids and nonsteroidal anti-inflammatories), and vaccination with the previous month

NEW STUDY Investigating Carboplatin Chemotherapy as a Post-Surgical treatment for Splenic Hemangiosarcoma in Dogs

Complete Title: Investigating Carboplatin Chemotherapy As Adjuvant Treatment For Canine Splenic Hemangiosarcoma

The goal of this study is to gain new insights on the efficacy and utility of carboplatin in the treatment of canine hemangiosarcoma.

Inclusion criteria:

  • Confirmed diagnosis of splenic hemangiosarcoma
  • Must have already undergone splenectomy
  • No evidence of metastasis
  • No previous chemotherapy treatment

NEW STUDY – Investigating Biomarkers of Metronomic Chemotherapy Treatment in Dogs with Soft Tissue Sarcoma

Complete Title: Investigating Biomarkers for Metronomic Cyclophosphamide Treatment of Canine Soft Tissue Sarcoma Using Functional Imaging, Tissue, and Blood Analysis

The objective of this study is to investigate the changes that occur inside the tumour using tissue and blood analysis for specific markers. These markers will be studied before and after 4 weeks of treatment.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of soft tissue sarcoma with gross disease

Companion Animal (Cats and Dogs) Tumour Sample Bank

Complete Title: Companion Animal Tumour Sample Bank

The objective of this bank is to allow for translation of cancer research throughout the University of Guelph and greater community to improve lives of those with companion animals that have cancer.

Inclusion criteria:

  • Companion animals with a confirmed diagnosis of cancer and the presence of a tumour

Analyzing Lymph Node Spread in Dogs Undergoing Surgery for Thyroid Tumours

Complete Title: Evaluation of Regional Lymph Node Metastasis in Canine Thyroid Carcinoma

The objective of this study will provide a more accurate idea of how often metastasis to the lymph nodes occurs in dogs with thyroid tumours or what effect that lymph node involvement has on prognosis. Specialized tissue staining may also help find deposits of cancer beyond routine staining techniques.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a thyroid tumour undergoing staging and surgery

Evaluating Outcomes Associated with Acute Myeloid Leukemia in Dogs

Complete Title: It’s All in the Genes – The Mutational Landscape of Acute Myeloid Leukemia in Dogs

The objective of this study is to learn more about the diagnosis and prognosis of different types of acute myeloid leukemia.

Inclusion criteria:

  • Dogs with a diagnosis of acute myeloid leukemia or myelodysplastic syndrome

Evaluating the Clinical Outcome of Dogs Diagnosed with T-cell Lymphoma

Complete Title: Prognostication of Canine T-cell Lymphoma

The objective of this study is to improve diagnosis and provide a more accurate prognosis for T-cell lymphomas.

Inclusion criteria:

  • Dogs with a cytology or histopathology diagnosis of lymphoma who will be treated with chemotherapy

Evaluating the Use of Fluorescent Dyes in Surgery to Improve Lymph Node Staging in Dogs with Lung Cancer

Complete Title: Evaluation of Sentinel Lymph Node Mapping in Dogs with Lung Tumours using CT Lymphography and Intraoperative Indocyanine Green

The objective of this study is to compare the accuracy of CT and intraoperative identification of sentinel (first draining) lymph nodes in dogs with lung tumours and to develop protocols for these methods of staging.

Inclusion criteria:

  • Dogs with a single lung tumour (less than 5cm) interested in pursing CT scan and surgery

Comparing the Use of Fluorescent Dyes in Surgery to Previously Reported Methods for Improving Lymph Node Staging in Dogs with Oral Cancer

Complete Title: Evaluation of Agreement Between Computed Tomography Lymphangiography and The Combination of Methylene Blue and Indocyanine Green for Sentinel Lymph Node Mapping in Dogs with Oral Tumours

The objective of this study is to evaluate the agreement between imaging and intraoperative techniques for identification of Sentinel Lymph nodes (SLNs) in canine patients with oral tumours. Development of these protocols could help decrease the number of lymph nodes surgically removed, in addition to ensuring accurate evaluation of the most important lymph node(s) for making follow-up treatment recommendations improving patient prognosis and outcomes for dogs diagnosed with oral tumours.

Inclusion criteria:

  • Dogs with a diagnosed oral tumour and interested in pursuing CT & Surgery

Gastrointestinal Lesions And Bleeding in Dogs With Mast Cell Tumours

Mast cell tumours (MCT) are a type of cancer of the skin and subcutaneous tissues that are relatively common in dogs. Mast cells are involved in the inflammatory response including the release of histamine, which increases stomach acidity. This can result in gastritis, vomiting, gastric ulcers and intestinal lesions in dogs with MCT.

Using a new, non-invasive technology (pill cameras) to obtain gastrointestinal (GI) tract images, the goal of this study is to better understand the prevalence of GI lesions in dogs with MCTs in order to better detect early lesions and overall, treat dogs with this cancer type.

Inclusion criteria:

  • Dogs (> 6 kg) with naturally occurring mast cell tumour disease 

Evaluating a Non-Invasive Heat Therapy For The Treatment of Bone Cancer in Dogs

Complete Title: Magnetic Resonance (MRI)-Guided High Intensity Focused Ultrasound (HIFU) to Treat Limb Osteosarcoma in Dogs: a Pilot Study

Bone cancer or osteosarcoma (OSA) is a common, highly aggressive cancer that can affect the long bones of large breed dogs. Current standard of care therapy consists of limb amputation plus chemotherapy. High-intensity focused ultrasound (HIFU) delivers ultrasonic energy that heats a target tissue above 60°C to produce tissue destruction without harming overlying and adjacent tissues within the path of the heat beam. It has been proposed that HIFU could be an alternative, non-surgical treatment which could provide an opportunity for the immune system to mount an immunity against OSA and could possibly reduce the frequency and/or speed of occurrence of metastasis.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of osteosarcoma with no evidence of metastases
  • No previous surgical/radiation treatment for treatment of OSA
  • Prior chemotherapy and/or bisphosphonate treatment will be evaluated on a case-by-case basis

Surgery


NEW STUDYEvaluating the Use of Fluorescence Dyes in Surgery to Identify Canine Pancreatic Cancer and Metastasis

Complete Title: Pilot Evaluation of Near Infrared Fluorescence Imaging for Intraoperative Identification of Canine Insulinoma and Their Metastasis

Near-infrared fluorescence imaging (NIRF) using Indocyanine Green (ICG), a fluorescent dye, has been previously used in a number of veterinary applications (many in clinical trials here at OVC). The use of NIRF for pancreatic mass resection in dogs has not yet been described but holds excellent potential for improving patient outcomes. The objective of this pilot study is to investigate the feasibility and utility of NIRF imaging for intraoperative characterization of pancreatic tumours and their metastases in dogs.

Inclusion criteria:

  • Dogs that are diagnosed with a pancreatic mass and scheduled for exploratory laparotomy

Evaluating the Use of Fluorescent Dyes in Surgery to Improve Lymph Node Staging in Dogs with Lung Cancer

Complete Title: Evaluation of Sentinel Lymph Node Mapping in Dogs with Lung Tumours using CT Lymphography and Intraoperative Indocyanine Green

The objective of this study is to compare the accuracy of CT and intraoperative identification of sentinel (first draining) lymph nodes in dogs with lung tumours and to develop protocols for these methods of staging.

Inclusion criteria:

  • Dogs with a single lung tumour (less than 5cm) interested in pursing CT scan and surgery

NEW STUDY Evaluating the Use of Fluorescent Dyes in Dogs Undergoing Gallbladder Removal Surgery

Complete Title: Evaluation of Indocyanine Green (ICG) Cholangiography in Dogs with Hepatobiliary Disease Undergoing Cholecystectomy

This study aims to determine the clinical usefulness of a safe fluorescent dye (indocyanine green, ICG) in canine patients with hepatobiliary disease scheduled to undergo gall bladder removal surgery by assessing whether it improves visualization of the biliary tree during surgery. 

Inclusion criteria: 

  • Any dog undergoing routine gall bladder removal surgery (open or laparoscopic cholecystectomy) during normal operating hours at the OVC

NEW STUDY – Exploring a Novel Diagnostic and Treatment Technique in Combination With Surgery for Thyroid Tumours in Dogs

Complete Title: Exploration of Nanoparticle-Enabled Image Exploration of Nanoparticle-Enabled Image Guided Photoblation in Veterinary Patients

PORPHYSOME-enabled therapies can have an immediate impact on cancer management providing better patient outcomes. This study will evaluate the potential applications of the novel nanomedicine (PORPHYSOMES) and PDT in veterinary clinical patients with thyroid tumours.

Inclusion Criteria:

  • Dogs with a confirmed freely moveable thyroid tumour interested in pursuing surgery are eligible

Comparison of Two Surgical Techniques and Long Term Outcomes to Alleviate Congenital Constriction in Dogs

Complete Title: Prospective, Long-Term Evaluation of Esophageal Function and Clinical Outcome Following Surgical Treatment of Vascular Ring Anomalies (VRA) in Dogs

The objective of this study is to evaluate the long term outcome following surgical treatment of VRA, specifically, objective data regarding clinical outcome and esophageal function.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a VRA undergoing CT scan and surgery

Evaluating the Use of Minimally Invasive Surgical Techniques for Dogs Presenting with Spontaneous Pneumothorax

Complete Title: Prospective Evaluation of Minimally Invasive Thoracic Surgery for Identification of Pulmonary Bullae in Dogs with Spontaneous Pneumothorax

The objective of this study is to evaluate the accuracy in identifying bubbles on the lungs during this technique.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a spontaneous pneumothorax undergoing traditional open surgery through the breast bone

Analyzing Lymph Node Spread in Dogs Undergoing Surgery for Thyroid Tumours

Complete Title: Evaluation of Regional Lymph Node Metastasis in Canine Thyroid Carcinoma

The objective of this study will provide a more accurate idea of how often metastasis to the lymph nodes occurs in dogs with thyroid tumours or what effect that lymph node involvement has on prognosis. Specialized tissue staining may also help find deposits of cancer beyond routine staining techniques.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a thyroid tumour undergoing staging and surgery

Comparing the Use of Fluorescent Dyes in Surgery to Previously Reported Methods for Improving Lymph Node Staging in Dogs with Oral Cancer

Complete Title: Evaluation of Agreement Between Computed Tomography Lymphangiography and The Combination of Methylene Blue and Indocyanine Green for Sentinel Lymph Node Mapping in Dogs with Oral Tumours

The objective of this study is to evaluate the agreement between imaging and intraoperative techniques for identification of Sentinel Lymph nodes (SLNs) in canine patients with oral tumours. Development of these protocols could help decrease the number of lymph nodes surgically removed, in addition to ensuring accurate evaluation of the most important lymph node(s) for making follow-up treatment recommendations improving patient prognosis and outcomes for dogs diagnosed with oral tumours.

Inclusion criteria:

  • Dogs with a diagnosed oral tumour and interested in pursuing CT & Surgery

Comparison of Two Surgical Techniques For The Treatment of Brachycephalic Airway Disease in French Bulldogs

Complete Title: Prospective, Randomized Trial Comparing Two Surgical Techniques For The Treatment of Brachycephalic Obstructive Airway Syndrome (BOAS) in French Bulldogs

Currently in veterinary patients, standard of care surgery for BOAS is a soft palate resection (staphylectomy). Given that some dogs still suffer from breathing difficulties following surgery, modifications that aim to provide a greater opening of the airway have been proposed. One of these procedures is the folded flap palatoplasty. The objective of this study is to compare the clinical outcome, by means of an exercise tolerance test and CT anatomy of traditional staphylectomy versus folded flap palatoplasty for the treatment in French bulldogs.

Inclusion criteria:

  • French bulldogs <5 years of age, with breathing difficulties as a result of BOAS and are interested in pursuing CT and surgery

Evaluating the Use of Fluorescent Dyes to Assess Blood Flow in Dogs Undergoing Intestinal Resection During Foreign Body Surgery

Complete Title: Use of Fluorescent Dyes for Perfusion Assessment and Surgical Planning for Foreign Body Surgery in Dogs

In human medicine, the use of fluorescent dyes like Indocyanine Green (ICG), have been found to decrease complications in bowel surgery. ICG has not yet been used for intestinal blood flow assessment in pets but might be helpful to reduce complications associated with poor blood flow including poor healing and leakage.

The objective of this study is to determine if using advanced technology and incorporating ICG in intestinal surgery in dogs can help surgeons assess intestine blood flow to potentially improve their surgical outcomes in the future.

Inclusion criteria: 

  • Dogs undergoing intestinal surgery for foreign body removal that require part of their intestines

Comparing Instrument Size for Liver Biopsy Collection in Small Dogs

Complete Title: Can Mini-Laparoscopy Instruments Provide Equivalent Diagnostic Samples in Routine Laparoscopic Liver Biopsy Procedures Performed in Small Dogs?

The purpose of this study is to determine if using smaller instruments for liver biopsies in small dogs can provide equivalent diagnostic answers to that obtained using standard instruments and would allow the procedure to be performed in future pets using smaller incisions and smaller instruments.

Inclusion criteria: 

  • Any dog 10kg or less scheduled for minimally invasive liver biopsy at the OVC

Questions about these studies?