Canine Surgical Clinical Trials

The Companion Animal Surgical Service at the Ontario Veterinary College offers neurosurgery, abdominal and thoracic surgery, cardiovascular and oncologic surgery, and reconstructive surgery. The Surgical Service also offers specialized techniques such as minimally invasive endoscopic surgery, laser procedures and hip replacements. To learn more about the Companion Animal Surgical Service at the OVC, please click here.

Exploring a Novel Diagnostic and Treatment Technique in Combination With Surgery for Thyroid Tumours in Dogs

Complete Title: Exploration of Nanoparticle-Enabled Image Exploration of Nanoparticle-Enabled Image Guided Photoblation in Veterinary Patients

PORPHYSOME-enabled therapies can have an immediate impact on cancer management providing better patient outcomes. This study will evaluate the potential applications of the novel nanomedicine (PORPHYSOMES) and PDT in veterinary clinical patients with thyroid tumours.

This project is part of the Veterinary Medical Innovation Platform aligned with Dr Michelle Oblak’s research chair with OVC and Animal Health Partners!

Inclusion Criteria:

  • Dogs with a confirmed freely moveable thyroid tumour interested in pursuing surgery are eligible

ON HOLD – Evaluation of a Fluorescent dye in Dogs with Hepatobiliary Disease Undergoing Gallbladder Removal Surgery

Complete Title: Evaluation of Indocyanine Green (ICG) Cholangiography in Dogs with Hepatobiliary Disease Undergoing Cholecystectomy

This study aims to determine the clinical usefulness of a safe fluorescent dye (indocyanine green, ICG) in canine patients with hepatobiliary disease scheduled to undergo gall bladder removal surgery by assessing whether it improves visualization of the biliary tree during surgery. 

Inclusion Criteria: 

  • Any dog undergoing routine gall bladder removal surgery (open or laparoscopic cholecystectomy) during normal operating hours at the OVC


Evaluating the Use of Fluorescence Dyes in Surgery to Identify Canine Pancreatic Cancer and Metastasis

Complete Title: Pilot Evaluation of Near Infrared Fluorescence Imaging for Intraoperative Identification of Canine Insulinoma and Their Metastasis

Near-infrared fluorescence imaging (NIRF) using Indocyanine Green (ICG), a fluorescent dye, has been previously used in a number of veterinary applications (many in clinical trials at OVC). The use of NIRF for pancreatic mass resection in dogs has not yet been described but holds excellent potential for improving patient outcomes.

Inclusion criteria:

  • Dogs that are diagnosed with a pancreatic mass and scheduled for exploratory laparotomy


The Use of Fluorescent Dyes to Evaluate Sentinel Lymph Nodes During Surgery for Dogs with Lung Tumours

Complete Title: Evaluation of Sentinel Lymph Node Mapping in Dogs with Lung Tumours using CT Lymphography and Intraoperative Indocyanine Green

By developing new protocols, we can ensure accurate evaluation of the most important lymph node(s) to make better follow-up and treatment recommendations. This will help to improve patient treatments and outcomes for dogs diagnosed with lung tumours, as well as dogs and cats with other solid tumour types in the future. The team is working closely with human surgeons on this translational project.

Inclusion criteria:

  • Dogs with a single lung tumour (less than 5cm) interested in pursing CT scan and surgery


Comparison of Two Surgical Techniques and Long Term Outcomes to Alleviate Congenital Constriction in Dogs

Complete Title: Prospective, Long-Term Evaluation of Esophageal Function and Clinical Outcome Following Surgical Treatment of Vascular Ring Anomalies (VRA) in Dogs

Vascular ring anomalies (VRA) are a result of
developmental abnormalities during fetal growth. Early surgical treatment of VRA is recommended to alleviate
the clinical signs and prevent long-term abnormalities
to the neuromuscular function of the esophagus. The objective of this study is to evaluate the clinical outcome and esophageal function following surgical treatment of VRA with traditional and minimally invasive techniques.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a VRA undergoing CT scan and surgery

Evaluating the Use of Minimally Invasive Surgical Techniques for Dogs Presenting with Spontaneous Pneumothorax

Complete Title: Prospective Evaluation of Minimally Invasive Thoracic Surgery for Identification of Pulmonary Bullae in Dogs with Spontaneous Pneumothorax

The objective of this study is to evaluate the accuracy in identifying bubbles on the lungs during this technique.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a spontaneous pneumothorax undergoing traditional open surgery through the breast bone


Analyzing Lymph Node Spread in Dogs Undergoing Surgery for Thyroid Tumours

Complete Title: Evaluation of Regional Lymph Node Metastasis in Canine Thyroid Carcinoma

The objective of this study will provide a more accurate idea of how often metastasis to the lymph nodes occurs in dogs with thyroid tumours or what effect that lymph node involvement has on prognosis. Specialized tissue staining may also help find deposits of cancer beyond routine staining techniques.

Inclusion criteria:

  • Dogs with a confirmed diagnosis of a thyroid tumour undergoing staging and surgery

Comparing the Use of Fluorescent Dyes in Surgery to Previously Reported Methods for Improving Lymph Node Staging in Dogs with Oral Cancer

Complete Title: Evaluation of Agreement Between Computed Tomography Lymphangiography and The Combination of Methylene Blue and Indocyanine Green for Sentinel Lymph Node Mapping in Dogs with Oral Tumours

Development of imaging and intraoperative protocols could help decrease the number of lymph nodes surgically removed, in addition to ensuring accurate evaluation of the most important lymph node(s) for making follow-up treatment recommendations improving patient prognosis and outcomes for dogs diagnosed with oral tumours.

Inclusion criteria:

  • Dogs with a diagnosed oral tumour and interested in pursuing CT & Surgery

Comparison of Two Surgical Techniques For The Treatment of Brachycephalic Airway Disease in French Bulldogs

Complete Title: Prospective, Randomized Trial Comparing Two Surgical Techniques For The Treatment of Brachycephalic Obstructive Airway Syndrome (BOAS) in French Bulldogs

Currently in veterinary patients, standard of care surgery for BOAS is a soft palate resection (staphylectomy). Given that some dogs still suffer from breathing difficulties following surgery, modifications that aim to provide a greater opening of the airway have been proposed. One of these procedures is the folded flap palatoplasty however a comparison of these techniques as it relates to clinical outcome has not been performed.

Inclusion criteria:

  • French bulldogs <5 years of age, with breathing difficulties as a result of BOAS and are interested in pursuing CT and surgery

ON HOLD at OVC, but open at collaborating US Sites Evaluating the Use of Fluorescent Dyes to Assess Blood Flow in Dogs Undergoing Intestinal Resection During Foreign Body Surgery

Complete Title: Use of Fluorescent Dyes for Perfusion Assessment and Surgical Planning for Foreign Body Surgery in Dogs

In human medicine, the use of fluorescent dyes like Indocyanine Green (ICG), have been found to decrease complications in bowel surgery. ICG has not yet been used for intestinal blood flow assessment in pets but might be helpful to reduce complications associated with poor blood flow including poor healing and leakage.

Inclusion Criteria: 

  • Dogs undergoing intestinal surgery for foreign body removal that require part of their intestines


Questions about these studies?